Chimica del morbo di Alzheimer:
Nature pubblica un articolo di Luca Ferrari, socio MCL

Luca Ferrari ha pubblicato sulla prestigiosa rivista Nature Communications un articolo che descrive un nuovo aspetto della complessa chimica del morbo di Alzheimer.

Nature Communications è un giornale scientifico “peer-reviewed” ad accesso libero pubblicato dalla Nature Research dal 2010.
Si occupa di scienze naturali, includendo fisica, chimica, scienze della terra, medicina e biologia. —  Wikipedia

Il paper è consultabile gratuitamente sul sito di Nature Cliccando qui per la visualizzazione a pagina web.
È inoltre possibile reperire la versione PDF, contenente informazioni e dati supplementari qui

Citiamo l’abstract del documento, per darvi un’anteprima della lettura, in lingua inglese.


“Aggregation of the Tau protein into fibrils defines progression of neurodegenerative diseases, including Alzheimer’s Disease. The molecular basis for potentially toxic reactions of Tau aggregates is poorly understood. Here we show that π-stacking by Arginine side-chains drives protein binding to Tau fibrils. We mapped an aggregation-dependent interaction pattern of Tau. Fibrils recruit specifically aberrant interactors characterised by intrinsically disordered regions of atypical sequence features. Arginine residues are key to initiate these aberrant interactions. Crucial for scavenging is the guanidinium group of its side chain, not its charge, indicating a key role of π-stacking chemistry for driving aberrant fibril interactions. Remarkably, despite the non-hydrophobic interaction mode, the molecular chaperone Hsp90 can modulate aberrant fibril binding. Together, our data present a molecular mode of action for derailment of protein-protein interaction by neurotoxic fibrils.”


Ferrari, L., Stucchi, R., Konstantoulea, K. et al. Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau. Nat Commun 11, 571 (2020). https://doi.org/10.1038/s41467-019-13745-7


Nature Communications is a peer-reviewed open access scientific journal published by the Nature Research since 2010. It covers the natural sciences, including physics, chemistry, earth sciences, medicine, and biology.